Investigation of cardiorespiratory effects of the selective 5?HT4 agonist BIMU?8 in etorphine?immobilised goats ( Capra aegagrus hircus ) in a randomized, blinded and controlled trial

Background Opioid-induced respiratory compromise remains a significant challenge in etorphine-immobilised wildlife. Serotonergic agonists offer potential avenue for preventing or treating opioid-induced compromise. We therefore aimed to determine whether the selective 5-hydroxytryptamine receptor 4 (5-HT4) agonist, BIMU-8, reverses goats. Methods Seven healthy adult goats were immobilised with etorphine, then treated BIMU-8 sterile water 5 minutes later randomised, prospective cross-over study. Cardiorespiratory variables measured at 1-minute intervals from before etorphine 15 after its administration. Arterial blood gas analyses also performed and administration respective treatments. Results Intravenous injection of attenuated etorphine-induced compromise, as indicated by improvements, compared baseline between treatments, rate (ƒR ), peripheral arterial oxygen saturation (SpO2 partial pressure (PaO2 ) alveolar-arterial gradient (P(A-a)O2 ). caused an increase heart temporary decrease pressure. Mild movements slight muscle spasm occurred but did not reverse immobilisation. Conclusion Our results indicate that may be drug candidate treatment, prevention, ungulates.